{
  "paper_doi": "10.7554/eLife.41925",
  "source_snapshot": "sources/sarvestani-2019.xml",
  "model_scope": "one leaky integrate-and-fire V1 simple cell driven by recorded LGN spike trains",
  "parameters": [
    {"name":"presynaptic LGN inputs","value":"1 to 50","provenance":"recorded inputs selected to form a simple-cell-like receptive field; exact selection must be recovered"},
    {"name":"simulation time step","value":0.1,"unit":"ms","provenance":"methods; numerical choice"},
    {"name":"simulation duration","value":89,"unit":"s","provenance":"methods; 18 white-noise blocks"},
    {"name":"resting voltage","value":-65,"unit":"mV","provenance":"methods and appendix; physiological model parameter"},
    {"name":"spike threshold","value":-55,"unit":"mV","provenance":"methods and appendix; simplified spike-generation rule"},
    {"name":"reset voltage","value":null,"unit":"mV","provenance":"unresolved: methods -60 mV; appendix -65 mV"},
    {"name":"refractory period","value":2,"unit":"ms","provenance":"methods and appendix"},
    {"name":"input resistance","value":47,"unit":"megohm","provenance":"methods describe a value based on in-vivo measurements"},
    {"name":"membrane time constant","value":6,"unit":"ms","provenance":"methods describe a value based on in-vivo measurements"},
    {"name":"implied capacitance","value":127.6595744680851,"unit":"pF","provenance":"derived by Felisyn: tau/R = 0.006 s / 47000000 ohm; not a new measurement"},
    {"name":"synaptic rise time","value":0.5,"unit":"ms","provenance":"methods and appendix; waveform equation must be checked against the implementation"},
    {"name":"synaptic decay time","value":2,"unit":"ms","provenance":"methods and appendix"},
    {"name":"synaptic latency","value":2,"unit":"ms","provenance":"appendix"},
    {"name":"excitatory reversal potential","value":0,"unit":"mV","provenance":"appendix"},
    {"name":"parameter assignments","value":10,"unit":"trials","provenance":"different randomized assignments of empirical synaptic-property triplets"}
  ],
  "missing_before_faithful_reproduction": [
    "an identified simulation entry point and its required input files",
    "the selected LGN units, spike times, receptive-field alignment and common stimulus timing",
    "empirical joint distributions of amplitude, variability and detectability, with conductance normalization",
    "random seeds and assignment order",
    "reset-voltage resolution and numerical integration details",
    "reference output arrays and interpretation of uncertainty"
  ],
  "interpretation_limits": [
    "the physiological sample uses anesthetized cats",
    "undetectable postsynaptic potentials are not direct measurements of vesicle release failure",
    "the input spike trains do not by themselves provide a model that encodes arbitrary new images",
    "this is not a full recurrent cortex or motor/feeding/decision circuit"
  ]
}